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Anti-Cancer Properties of Mangosteen

Cancer is not just one type of malformed cell that invades the body and ultimately kills. There are several types of cancer cells that can harm your body. To try and prevent or cure these various cancers, researchers have looked at various natural products. One such product is a plant called Mangosteen. This plant is found in Southeast Asia and has been used for centuries to cure various ailments. Many cultures in Southeast Asia have used Mangosteen to heal wounds, act as an antihistamine, and antioxidant. Researchers from numerous universities have developed studies to test the healing abilities of the plant. It was discovered that the plant rind or peel is where most of the healing properties reside, rather than in the fruit. For this reason, several Mangosteen juices also contain rind, after it has been processed to gain Mangosteen Xanthones and Alpha-Mangostin. Among the studies completed are four relevant studies conducted on cancer cells. These studies show there are anti-cancer benefits to Mangosteen.

Mangosteen and its Effect on Liver Cancer

A study conducted by the Department of Medical Research and Education at Veterans General Hospital in Taipei, ROC was released in 2002. The study examined the effects of Mangosteen Xanthones on liver cancer.

Using chromatography, researchers extracted 6 xanthone compounds from Garcinia Mangostana L or the Mangosteen rind. These compounds were tested on 14 different types of human cancer cells. An assay, which tests ingredients and quality of said compound, was conducted to determine the effects the 6 xanthones would have on the 14 cancer cells. It was found that compound Garcinone E did have a cytotoxic effect on liver cancer, as well as on gastric and lung cancer cells. The study strongly believes that Garcinone E can be used to treat nearly all 14 human cancer cells treated.

However, the results are not conclusive from this study. A combination of chemotherapy and Garcinone E did not show positive results, but nor were the results negative.

Mangosteen Inhibits Breast Cancer Cell Growth

A second study, this time conducted by the Department of Microbiology in the Faculty of Pharmacy at Mahidol University in Rajdhevee, Bangkok, Thailand examined the effects of Mangosteen on breast cancer cells. The study was devised to examine antiproliferative effects, meaning an agent could be used to inhibit cell growth, of Mangosteen on breast cancer cells. The study also examined the apoptotic and antioxidant effects of the fruit. Apoptotic or apoptosis is a process of cell destruction using marked nuclear DNA to stop cancer cell growth.

In the study, crude methanolic extract (CME) taken from the Mangosteen fruit was used to fight breast cancer in humans. With 9.25+/-0.64 microg/ml CME Mangosteen compound, researchers saw an antiproliferative effect on breast cancer. It was also discovered that with different incubation and concentrations of CME, ROS production of cancer cells was inhibited. It indicates that Mangosteen compound CME can be used to treat breast cancer with success by causing antiproliferation, antioxidation, and apoptosis in the cells. Using this compound is time and dose dependent and can lead to cancer chemoprevention, according to the study.

Xanthones from Mangosteen Inhibit Kidney Cancer, Breast Cancer, and Melanoma

In 2002, Bioorg Med Chem journal published an article from a Porto, Portugal medical study conducted at the Fitoquimic e Farmacologia da Universidade do Porto. The study looked at 27 oxygenated xanthones, some of which were removed from Mangosteen rinds. Using in vitro procedures of human cancer cells from breast cancer, renal cancer, and melanoma, scientists tested to see if the xanthones would work as antiproliferatives. There was a difference in potency for the inhibitory qualities of these xanthones, and no conclusion was made. However, there was evidence to suggest that with the right compound extraction from Mangosteen, a patient may be able to prevent certain human cancer cells from growing.

Leukemia Inhibition Using Mangosteen

The Gifu International Institute of Biotechnology in Japan studied the apoptosis of human leukemia cell lines using Xanthones from Mangosteen. In this study 6 xanthones were extracted from Mangosteen peels to test against the growth of leukemia cells HL60. Alpha-Mangostin was one of the xanthones used to test for apoptosis of the cancer cells. Using 10 mciroM, Alpha-Mangostin was able to completely inhibit HL60 cell growth.

Further study is required for the anti-cancer properties in Mangosteen. However, there are no results showing that drinking juice with Mangosteen xanthones, such as Alpha-Mangostin, would be detrimental to your health. In fact, it is the opposite. The results show promise in helping you fight cancer and other ailments by drinking Mangosteen xanthone based juices.

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