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Antihistamines are compounds that help stop or inhibit the activity of histamine receptors. These compounds are designed to prevent allergy symptoms. There is an organic compound that is nitrogenous in nature called histamine. Histamine can create an inflammatory response in the body, as well as stimulate the immune system to react to certain allergens. Histamine can also increase the white blood cell permeability in the capillaries and in certain proteins, which can affect tissues in the body.
When a person has an allergy to pollen, their eyes can become inflamed, red, and watery. This is the histamine response. Their nose can also feel full and their sinuses “stuffed up.” It is all an immune system response that provides “cold” like symptoms such as a runny nose, ear pain, sore throat, and for some even a cough.
You might be tired of the chemical compounds sold as antihistamines. These drugs are designed to inhibit your body’s immune response and clear up your nose, eyes, and throat for better breathing. Unfortunately, you have probably found you develop an immunity to these medications, so their effects do not last as long as promised. Claritin, for example, promises all day relief, but for many it provides two hours at most.
If you are looking for a better product to solve your histamine problems, consider the studies conducted on Mangosteen, a fruit from Malaysia, and its inhibitory activity relating to histamine release. Mangosteen has been around for centuries and used in Southeast Asia to cure various ailments, including histamine responses triggered in the body.
The Department of Pharmaceutical Molecular Biology at the Graduate School of Pharmaceutical Sciences at Tohoku University, in Sendai, Japan conducted a study examining Mangosteen and its effects on histamine inhibition. The study was published in 2002. The results of their study proved that a 40% ethanol extract of Mangosteen was able to inhibit histamine release. Note that this was not the juice or the fruit eaten. It was a chemical extraction of certain Mangosteen properties in an ethanol extraction process.
Another study was also conducted in 1997 by the same department. This time a methanolic extract made from the fruit rind of Mangosteen was used to determine if the fruit could be used as an anti-histamine. The study was conducted on a rabbit aorta. The study showed that the histamine was inhibited by the introduction of Mangosteen extracts.
Alpha-Mangostin as it is called is an antagonist of histamine H1 receptor. The receptor is where a cell, in this case a histamine cell, fits into another cell to start an immune reaction. When an antagonist receptor is present it can bond with the immune cell and inhibit the histamine from bonding instead.
These two studies prove that the right compound of Mangosteen can provide you relief from your histamine reactions, which are usually an allergic reaction to plants, animals, or other things you may come into contact, including food. If you are seeking relief from your histamine reactions, consider finding a product that has an Alpha-Mangostin compound, such as a juice that contains this property.